Meanwhile, the new Oscorp CEO, Alistair Smythe, attempts to develop his own cure so that he will be credited as the city's savior, and to eliminate Spider-Man and Connors for interfering with his plans. Months after the events of the film, a number of cross-species experiments created by Oscorp using Curt Connors' research escape into Manhattan and infect its population with a deadly virus, forcing Spider-Man to join forces with Gwen Stacy and Connors to find a cure.

Its story serves as an alternate epilogue to The Amazing Spider-Man film, which is continued in the game's sequel. The game was directed by Gerard Lehiany and written by Seamus Kevin Fahey, Benjamin Schirtz and Gérard Lehiany. A sequel, The Amazing Spider-Man 2, was released in April 2014, itself based on the film.

A PlayStation Vita version was released in November 2013. A version for the Wii U was released in March 2013 in North America and Europe known as The Amazing Spider-Man: Ultimate Edition in both regions. It was released on June 26 in North America and on Jin Europe for the Nintendo DS, PlayStation 3, Xbox 360, Wii, Android, iOS, and Microsoft Windows. It was developed by Beenox and published by Activision.

The Amazing Spider-Man is an open world video game based on the Marvel Comics character Spider-Man and the 2012 film of the same name.

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